USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: CALR_HUMAN USC-OGP 2-DE database:  CALR_HUMAN CALR_HUMAN General information about the entry View entry in simple text format Entry name CALR_HUMAN Primary accession number P27797 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Calreticulin; AltName: Full=CRP55; AltName: Full=Calregulin; AltName: Full=Endoplasmic reticulum resident protein 60; Short=ERp60; AltName: Full=HACBP; AltName: Full=grp60; Flags: Precursor;. Gene name Name=CALR Synonyms=CRTC Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0043: pI=4.45; Mw=56770 SPOT OGP-0089: pI=4.45; Mw=43243 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1144: pI=4.46; Mw=58238 Cross-references UniProtKB/Swiss-Prot P27797; CALR_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name CALR_HUMAN Primary accession number P27797 Secondary accession number(s) Q6IAT4 Q9UDG2 Sequence was last modified on  August 1, 1992 (version 1) Annotations were last modified on  March 15, 2017 (version 206) Name and origin of the protein Description RecName: Full=Calreticulin; AltName: Full=CRP55; AltName: Full=Calregulin; AltName: Full=Endoplasmic reticulum resident protein 60; Short=ERp60; AltName: Full=HACBP; AltName: Full=grp60; Flags: Precursor; Gene name Name=CALR Synonyms=CRTC Encoded on Name=CALR; Synonyms=CRTC Keywords 3D-structure; Acetylation; Calcium; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Extracellular matrix; Glycoprotein; Lectin; Metal-binding; Reference proteome; Repeat; Sarcoplasmic reticulum; Secreted; Signal; Zinc. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M32294; AAA36582.1; -; mRNA EMBL M84739; AAA51916.1; -; mRNA EMBL AY047586; AAL13126.1; -; mRNA EMBL AB451408; BAG70222.1; -; mRNA EMBL BT007448; AAP36116.1; -; mRNA EMBL CR457070; CAG33351.1; -; mRNA EMBL AD000092; AAB51176.1; -; Genomic_DNA EMBL CH471106; EAW84331.1; -; Genomic_DNA EMBL BC002500; AAH02500.1; -; mRNA EMBL BC007911; AAH07911.1; -; mRNA EMBL BC020493; AAH20493.1; -; mRNA CCDS CCDS12288.1; -; . PIR A42330; A37047; . RefSeq NP_004334.1; NM_004343.3; . UniGene Hs.515162; -; . PDB 2CLR; X-ray; 2.00 A; C/F=1-10 PDB 3DOW; X-ray; 2.30 A; B=195-205 PDB 3POS; X-ray; 1.65 A; A/B/C=18-204 A/B/C=302-368 PDB; 3POW; X-ray; 1.55 A A=18-204 A=302-368; PDB; 5LK5; X-ray 2.30 A A/B/C/D/E/F/G/H/I/J=18-204; A/B/C/D/E/F/G/H/I/J=303-368; PDBsum; 2CLR PDBsum 3DOW; -; . PDBsum 3POS; -; . PDBsum 3POW; -; . PDBsum 5LK5; -; . DisProt DP00333; -; . ProteinModelPortal P27797; -; . SMR P27797; -; . BioGrid 107262; 126; . DIP DIP-104N; -; . IntAct P27797; 42; . MINT MINT-101756; -; . STRING 9606.ENSP00000320866; -; . DrugBank DB00025; Antihemophilic Factor (Recombinant); . DrugBank DB01065; Melatonin; . DrugBank DB00031; Tenecteplase; . iPTMnet P27797; -; . PhosphoSitePlus P27797; -; . SwissPalm P27797; -; . BioMuta CALR; -; . DMDM 117501; -; . DOSAC-COBS-2DPAGE P27797; -; . OGP P27797; -; . REPRODUCTION-2DPAGE IPI00020599; -; . SWISS-2DPAGE P27797; -; . UCD-2DPAGE P27797; -; . EPD P27797; -; . PaxDb P27797; -; . PeptideAtlas P27797; -; . PRIDE P27797; -; . TopDownProteomics P27797; -; . DNASU 811; -; . Ensembl ENST00000316448; ENSP00000320866; ENSG00000179218; . GeneID 811; -; . KEGG hsa:811; -; . CTD 811; -; . DisGeNET 811; -; . GeneCards CALR; -; . HGNC HGNC:1455; CALR; . HPA CAB001513; -; . HPA CAB019952; -; . HPA HPA002242; -; . MalaCards CALR; -; . MIM 109091; gene; . neXtProt NX_P27797; -; . OpenTargets ENSG00000179218; -; . Orphanet 3318; Essential thrombocythemia; . Orphanet 824; Myelofibrosis with myeloid metaplasia; . PharmGKB PA26046; -; . eggNOG KOG0674; Eukaryota; . eggNOG ENOG410XRR7; LUCA; . GeneTree ENSGT00430000030841; -; . HOGENOM HOG000192435; -; . HOVERGEN HBG005407; -; . InParanoid P27797; -; . KO K08057; -; . OMA IANPEYV; -; . OrthoDB EOG091G0AP1; -; . PhylomeDB P27797; -; . TreeFam TF338438; -; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-168316; Assembly of Viral Components at the Budding Site; . Reactome R-HSA-3000480; Scavenging by Class A Receptors; . Reactome R-HSA-3000484; Scavenging by Class F Receptors; . Reactome R-HSA-381183; ATF6 (ATF6-alpha) activates chaperone genes; . Reactome R-HSA-901042; Calnexin/calreticulin cycle; . Reactome R-HSA-983170; Antigen Presentation: Folding; assembly and peptide loading of class I MHC; . ChiTaRS CALR; human; . EvolutionaryTrace P27797; -; . GeneWiki Calreticulin; -; . GenomeRNAi 811; -; . PRO PR:P27797; -; . Proteomes UP000005640; Chromosome 19; . Bgee ENSG00000179218; -; . CleanEx HS_CALR; -; . ExpressionAtlas P27797; baseline and differential; . Genevisible P27797; HS; . GO GO:0001669; C:acrosomal vesicle; IEA:Ensembl; . GO GO:0009986; C:cell surface; TAS:BHF-UCL; . GO GO:0005737; C:cytoplasm; IDA:BHF-UCL; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0071682; C:endocytic vesicle lumen; TAS:Reactome; . GO GO:0005783; C:endoplasmic reticulum; TAS:UniProtKB; . GO GO:0005788; C:endoplasmic reticulum lumen; IDA:UniProtKB; . GO GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; TAS:Reactome; . GO GO:0009897; C:external side of plasma membrane; IEA:Ensembl; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0005794; C:Golgi apparatus; IEA:Ensembl; . GO GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome; . GO GO:0005622; C:intracellular; TAS:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0042824; C:MHC class I peptide loading complex; ISS:BHF-UCL; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL; . GO GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome; . GO GO:0005844; C:polysome; IDA:BHF-UCL; . GO GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell; . GO GO:0033018; C:sarcoplasmic reticulum lumen; IEA:UniProtKB-SubCell; . GO GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl; . GO GO:0050681; F:androgen receptor binding; IDA:BHF-UCL; . GO GO:0005509; F:calcium ion binding; ISS:UniProtKB; . GO GO:0030246; F:carbohydrate binding; TAS:BHF-UCL; . GO GO:0051087; F:chaperone binding; TAS:BHF-UCL; . GO GO:0001849; F:complement component C1q binding; TAS:BHF-UCL; . GO GO:0003677; F:DNA binding; NAS:UniProtKB; . GO GO:0001948; F:glycoprotein binding; IPI:UniProtKB; . GO GO:0042562; F:hormone binding; IEA:Ensembl; . GO GO:0005178; F:integrin binding; IPI:BHF-UCL; . GO GO:0005506; F:iron ion binding; IEA:Ensembl; . GO GO:0003729; F:mRNA binding; IDA:BHF-UCL; . GO GO:0042277; F:peptide binding; IEA:Ensembl; . GO GO:0044183; F:protein binding involved in protein folding; TAS:BHF-UCL; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB; . GO GO:0051082; F:unfolded protein binding; TAS:BHF-UCL; . GO GO:0008270; F:zinc ion binding; TAS:BHF-UCL; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome; . GO GO:0036500; P:ATF6-mediated unfolded protein response; TAS:Reactome; . GO GO:0055007; P:cardiac muscle cell differentiation; IEA:Ensembl; . GO GO:0006874; P:cellular calcium ion homeostasis; TAS:UniProtKB; . GO GO:0071285; P:cellular response to lithium ion; IEA:Ensembl; . GO GO:0090398; P:cellular senescence; IGI:BHF-UCL; . GO GO:0061077; P:chaperone-mediated protein folding; IEA:Ensembl; . GO GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl; . GO GO:0042921; P:glucocorticoid receptor signaling pathway; TAS:BHF-UCL; . GO GO:0071157; P:negative regulation of cell cycle arrest; IGI:BHF-UCL; . GO GO:0033144; P:negative regulation of intracellular steroid hormone receptor signaling pathway; IDA:BHF-UCL; . GO GO:0045665; P:negative regulation of neuron differentiation; IDA:BHF-UCL; . GO GO:0048387; P:negative regulation of retinoic acid receptor signaling pathway; IDA:BHF-UCL; . GO GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL; . GO GO:0045892; P:negative regulation of transcription; DNA-templated; IDA:BHF-UCL GO GO:0017148; P:negative regulation of translation; IDA:BHF-UCL; . GO GO:0002502; P:peptide antigen assembly with MHC class I protein complex; ISS:BHF-UCL; . GO GO:0045787; P:positive regulation of cell cycle; IGI:BHF-UCL; . GO GO:0008284; P:positive regulation of cell proliferation; IGI:BHF-UCL; . GO GO:2000510; P:positive regulation of dendritic cell chemotaxis; IMP:UniProtKB; . GO GO:0045740; P:positive regulation of DNA replication; IGI:BHF-UCL; . GO GO:0010628; P:positive regulation of gene expression; IEA:Ensembl; . GO GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl; . GO GO:0050766; P:positive regulation of phagocytosis; ISS:BHF-UCL; . GO GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IMP:UniProtKB; . GO GO:0006611; P:protein export from nucleus; IDA:UniProtKB; . GO GO:0006457; P:protein folding; TAS:BHF-UCL; . GO GO:0034975; P:protein folding in endoplasmic reticulum; TAS:ParkinsonsUK-UCL; . GO GO:0034504; P:protein localization to nucleus; IDA:UniProtKB; . GO GO:0022417; P:protein maturation by protein folding; TAS:BHF-UCL; . GO GO:0050821; P:protein stabilization; ISS:UniProtKB; . GO GO:0006898; P:receptor-mediated endocytosis; TAS:Reactome; . GO GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB; . GO GO:0040020; P:regulation of meiotic nuclear division; IEA:Ensembl; . GO GO:0006355; P:regulation of transcription; DNA-templated; TAS:ProtInc GO GO:0042493; P:response to drug; IEA:Ensembl; . GO GO:0032355; P:response to estradiol; IEA:Ensembl; . GO GO:0033574; P:response to testosterone; IEA:Ensembl; . GO GO:0051208; P:sequestering of calcium ion; TAS:BHF-UCL; . GO GO:0007283; P:spermatogenesis; IEA:Ensembl; . GO GO:1990668; P:vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane; TAS:Reactome; . Gene3D 2.10.250.10; -; 1; . Gene3D 2.60.120.200; -; 2; . InterPro IPR001580; Calret/calnex; . InterPro IPR018124; Calret/calnex_CS; . InterPro IPR009169; Calreticulin; . InterPro IPR009033; Calreticulin/calnexin_P_dom; . InterPro IPR013320; ConA-like_dom; . PANTHER PTHR11073; PTHR11073; 1; . Pfam PF00262; Calreticulin; 2; . PIRSF PIRSF002356; Calreticulin; 1; . PRINTS PR00626; CALRETICULIN; . SUPFAM SSF49899; SSF49899; 1; . SUPFAM SSF63887; SSF63887; 1; . PROSITE PS00803; CALRETICULIN_1; 1; . PROSITE PS00804; CALRETICULIN_2; 1; . PROSITE PS00805; CALRETICULIN_REPEAT; 3; . PROSITE PS00014; ER_TARGET; 1; .

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